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Ibutamoren Mesylate


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What Is Ibutamoren Mesylate MK-677 ?


Ibutamoren Mesylate (MK-677) is a chemical that has the characteristics of human growth hormone (HGH).  It is an orally active growth hormone secretagogue.  A secretagogue causes substances to be secreted.  MK677 has the ability because of its ability to mimic the GH stimulating action a hormone called “ghrelin.”  Ghrelin is categorized as a peptide, commonly referred to as “the hunger hormone,” which explains the drastic rise in appetite with 677 use.  Ghrelin plays a large role in regulating the distribution as well as rate of energy use.  It is imperative to understand all of these concepts to decipher the many capabilities that 677 has.  mk677 can not only increase plasma levels of many types of hormones, but also provide sustainable increases.  These are long term and not just “for the time being” types of increases.  Studies show that Ibutamoren Mesylate can increase muscle mass and bone mineral density as well as altering the metabolism of body fat, possibly becoming a treatment for obesity.


Benefits of MK-677:


Ibutamoren Mesylate (MK-677) studies have been conducted since the late 90's.  There is a wide array of benefits that have been found with use.  The main benefit that consistently shows in study is the increase in growth hormone and IGF-levels provided with use.  These have shown to be significant increases in regards to both.  Below is a list of other significant benefits found through studies and implementation on humans:


        Increases in fat free mass - Enhanced sleep quality - A treatment for obesity and fat loss - Lowering of bad cholesterol (LDL) - Significant improvements in nitrogen balance - Reversal of diet-induced nitrogen wasting - Treatment of catabolic conditions - Increase in basil metabolic rate  - Oral administration (no injections required) - Overall sense of well-being


It is evident by the list of benefits that MK677 is highly desirable.  These benefits, in conjunction with the very small chance of side effects show MK677 to be a breakthrough.


Side Effects:


As stated above, MK677 carries little to no side effects however it is always important to understand the possibilities that could occur with use.


The main “side effect” associated with MK677 is the increase in appetite, which may be welcome by many research subjects.  Studies show this to subside after 4-8 weeks, variant from person to person.  The other side effects that showed, that were very infrequent and uncommon were mild lower extremity edema and muscle pain.  Secretagogues generally carry the worry of prolactin increase, however studies with MK677 did not show any increase in prolactin levels.  Cortisol levels were not increased in studies either.  These traits make Ibutamoren Mesylate stand out amongst other chemicals that attempt to work in the same manner but carry these unwanted side effects.




Studies conducted had dosing between 5-25 mg per day, with 25 mg being the most common and effective dose.  MK677 has a 24 hour half life and showed to be best tolerated when fed to rats each morning on an empty stomach.  MK677 has extreme benefits in regards to helping with a deeper sleep however it can interfere with sleep patterns if taken too late at night or too close to bed time.  MK677 can be used continuously for 1-2 years with no concern of desensitizing.


Recommended Dosage :


Month 1 - 10mg once daily

Month 2 - 20mg once daily

Month 3 - 30mg once daily


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