What is S23?
S23 is an orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM) that has been proven to increase lean muscle and bone tissue while being tissue selective (unlike traditional steroids).
Studies and user reports suggest that S23 is the closest SARM to steroids, with a few key differences, such as decreased prostate size. Other user reports suggest that S23 is a much more powerful version of S4 Andarine) and the benefits of this SARM falls in the category of hardening muscle and creating a grainier aesthetic look.
Read on for a comprehensive review of everything you need to know about S23, including benefits, side effects, studies and results for increasing muscle mass and preserving gains.
S23 is currently being investigated by GTX, a pharmaceutical company that primarily develops hormonal drugs, including a number of other SARMs. Interestingly, S23 is being investigated as a potential male hormonal contraceptive as studies have shown dose-dependent suppression of sperm.
How it works
As a member of the SARM category, S23 works to selectively target and produce anabolic results in muscle and bone tissue without some of the limitations and side effects of traditional steroids.
Benefits of S23
Many users and studies suggest that S23 is one of the most powerful SARMs on the market. We’ve listed the primary benefits you can expect when taking S23.
S23 helps build lean muscle mass.The number one benefit of supplementing with S23 is its ability to increase lean body mass. The second core benefit is the proven ability to retain gains after completing a cycle, as shown in this study. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630904/
S23 can increase strength and stamina during high-intensity workouts.Want to work out longer, harder and get better results every time you hit the gym? Users report enhanced speed, stamina, and endurance during workouts when supplementing with S23.
Additionally, thanks to its ability to increase lean muscle tissue and decrease fat, high-intensity workouts and interval training can be optimized every time.One thing to note, however, is a user-reported side effect of increased anger whilst supplementing with S23, which may be a factor in increased effort and intensity during a workout.
S23 can increase fat loss .S23 is to increase fat loss and fat oxidization.The study showed that rats treated with S23 increased lean muscle mass and bone mineral density whilst simultaneously reducing fat loss percentage. Interestingly, this study shows that there is an inverse relationship between a higher dose of S23 and a decrease in body fat. This suggests that a higher dose of S23 results increased fat loss.
S23 shows minimal water retention.Water retention isn’t all bad. Some users suggest that water retention and bloating experienced during bulking periods can help to lubricate and protect joints. But S23 has been shown to offer minimal (if any) water retention and bloating, which means that all gains during a cycle will be retained. The fact that S23 does not cause water retention makes it ideal for cutting periods.
S23 can help develop a harder and grainier muscle aesthetic. Some users suggest using S23 to maintain and build lean muscle whilst cutting, as this SARM tends to develop dry, grainy-looking muscles that are otherwise unattainable without traditional steroids. Many bodybuilders find S23 ideal in the lead up to competitions in order to create the level of muscular detail that wins competitions.
Below are some of the typical side effects associated with taking the S23 SARM, each one in further detail…
Testosterone shutdown.S23 is the most potent SARM to date and has been suggested to be as close to traditional steroids as possible. With this in mind, the side effects of S23 are dissimilar to other SARMs, in that it does actually show an effect on testosterone levels in the form of complete down. Users report minimizing or even eliminating this side effect by supporting their supplementation of S23 with Testosterone Replacement Therapy (TRT).
These side effects were completely reversed in studies upon cessation of S23 and the completion of a full PCT.
Increased aggression.Some users report increased aggression when supplementing with S23, which could be a deterrent to some users with known anger issues.
Testicle and prostate shrinkage.Temporary shrinkage of the testicles has been noted by some users, and the primary study on S23 shows prostate shrinkage. However, it’s worth noting that even with its similarities to steroids, the decrease in prostate size is unusual as steroids normally cause an increase, which can cause issues.Users note that testicle shrinkage was reversible once supplementation was stopped.
Darker urine.Some users report darker-than-usual urine while cycling S23. This stopped when the cycle was complete.
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