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What is TB500?
TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB500). It is a first-in-class drug candidate that promotes the following*:
Endothelial (blood vessels) cell differentiation
Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
Collagen deposition; and
One of TB500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.
This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. TB500 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.
TB500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.
An additional key factor of TB500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
Research confirms that TB500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TB500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.
TB-500 offers many benefits to the equine world in performance racing. Recent trials by some of the world’s leading trainers on their prize winning equine members of both genders, have been credited by a huge boost in their race-day results, something long desired in the racing world.
These trials along with clinical trials have indicated the following benefits associated with the use of TB-500 on mares and stallions*:
Increased muscle growth with huge increases in endurance and strength noted
Relaxed muscle spasm
Improved muscle tone
Increases the exchange of substance between cells
Encourages tissue repair
Stretches connective tissue
Helps maintain flexibility
Reduces inflammation of tissue in joint
Enhances nutritional components in the animal
Prevents the formation of adhesions and fibrous bands in muscles, tendons and ligaments.
When these proven benefits are viewed in conjunction with the fact that 60% of a horse’s body weight is muscle, it is clear to see the full potential of TB500can be reveled in by majority of the horse’s body.
Can TB-500 be used in conjunction with other supplements or anti-biotics?
As TB-500 is a synthetic version of the naturally occurring peptide found in all animal cells, it does not pose as a foreign substance to the body. This means the product can be safely used in conjunction with any supplement or anti-biotic and not compromise the effect of these substances.
What are the side effects of using TB-500?
Post clinical safety trials and trials with some of the world’s most renowned equine trainers, there have been no noted side effects with the use of TB-500. It is not an oil-based solution and therefore poses no threat to the exterior complexion of the animal. One side effect which can be taken as being adverse at times is the increase in energy levels experienced by the animal. While in training and on the race track this poses a huge benefit, in recovery spells and transport between stables this can become a problem.
How often can TB-500 be administered?
Horses - Use one 10mg vial every week for a 6 week period
Greyhound - Use half of one 10mg vial every week for 6 weeks
Do I have to keep TB-500 refrigerated?
TB-500 does not require refrigeration. It is to be stored at room temperature in a non humid environment. However, for greyhound usage where only half a vial (1ml) is used at a time, it is advised the vial be refrigerated and used within an 8 day period.
Does TB-500 contain any illegal or banned substances?
TB-500 is 100% drug free and chemical free. As a result,TB-500 DOES NOT SWAB.
What is the purity of TB500
TB500 is 95% pure and ranks as one of the highest purity sources of Thymosin Beta 4 available in the world.
Our Recommended Dosage
Inject 1ml bacteriostatic water into vial.
Draw out Entire vial contents and inject once a week for serious injury
or every fortnight for mild injury or on improvement of serious injury.
Subcutaneous at site of pain
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