Brain Region Responsiveness
Clinical Test Expectation – MIF-1 – 50MG – Human Subjects : Strong Depression helper and Parkinsons disease assistance
Strength – 50MG per vial
Introduction.
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier
MIF-1 (Pro-Leu-Gly-NH2) is a tripeptide for which the therapeutic potential in Parkinson’s disease and depression has been indicated by many studies. However, the cellular mechanisms of action of MIF-1 are not yet clear. Here, we show the specific brain regions responsive to MIF-1 treatment by c-Fos mapping, and determine the kinetics of cellular signaling by western blotting of pERK, pSTAT3, and c-Fos in cultured neurons. The immunoreactivity of c-Fos was increased 4 hours after MIF-1 treatment in brain regions critically involved in the regulation of mood, anxiety, depression, and memory. The number of cells activated was greater after peripheral treatment (intravenous delivery) than after intracerebroventricular injection. In cultured SH-SY5Y neuronal cells, c-Fos was induced time- and dose-dependently. The activation of cellular c-Fos was preceded by a transient increase of mitogen-activated protein kinase pERK but a reduction of phosphorylated Signal Transducer and Activator of Transcription (pSTAT3) initially. We conclude that MIF-1 can modulate multiple cellular signals including pERK, and pSTAT3 to activate c-Fos. The cellular activation in specific brain regions illustrates the biochemical and neuroanatomical basis underlying the therapeutic effect of MIF-1 in Parkinson’s disease and depression.
Dosing Details
You inject 2ml water into the vial of MIF-1 from the water vial. 1 full syringe is 1ml. you then wait for the vial powder content to dissolve and once dissolved and clear you draw out 40 (4 units / 10 MG) and inject it into the tummy under the skin into the fatty skin layer
How long will a vial last ?
A vial should last 5 days.
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| Weight | 1 g |
|---|---|
| Dimensions | 4 × 1,5 × 9 cm |
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